Acquisition of iron from human transferrin by Porphyromonas gingivalis: a role for Arg‐ and Lys‐gingipain activities

Abstract excerpt

Porphyromonas gingivalis, a key causative agent of adult periodontitis, is known to produce a variety of virulence factors including proteases. The aim of this study was to evaluate the participation of Arg- and Lys-gingipain activities of P. gingivalis in the acquisition of iron from human transferrin and its subsequent utilization in growth. Iron-saturated transferrin was found to support the long-term growth...

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