Article
Male breast cancer in Cowden syndrome patients with germline PTEN mutations.
Journal of medical genetics - 1 Mar 2001
Fackenthal J D, Marsh D J, Richardson A L, Cummings S A, Eng C, Robinson B G, Olopade O I
Abstract excerpt
Cowden syndrome (CS) (OMIM 158350) is a multiple hamartoma syndrome associated with germline mutations in the PTEN tumour suppressor gene. While CS is characterised most commonly by non-cancerous lesions (mucocutaneous trichilemmomas, acral and palmoplantar keratoses, and papillomatous papules), it is also associated with an increased susceptibility to breast cancer (in females) and thyroid cancer, as well as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.