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Trichilemmomas show loss of PTEN in Cowden syndrome but only rarely in sporadic tumors

7 Feb 2012

Abstract excerpt

BACKGROUND: Trichilemmoma (TL) can occur as a solitary sporadic lesion usually on the face or as multiple facial lesions almost invariably associated with Cowden syndrome (CS). CS is a multisystem disorder caused by a germline inactivating mutation in PTEN (10q23.31), a tumor suppressor gene. We sought to identify PTEN loss by immunohistochemistry (IHC) in sporadic and CS-associated TL to determine whether IHC is...

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PMID: 22486434
DOI: 10.1111/j.1600-0560.2012.01888.x

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