Article
Mutation processes at the protein level: is Lamarck back?
Mutation research - 1 Mar 2001
Chernoff Y O
Abstract excerpt
The experimental evidence accumulated for the last half of the century clearly suggests that inherited variation is not restricted to the changes in genomic sequences. The prion model, originally based on unusual transmission of certain neurodegenerative diseases in mammals, provides a molecular mechanism for the template-like reproduction of alternative protein conformations. Recent data extend this model to...
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