Article
RegA proteins from phage T4 and RB69 have conserved helix-loop groove RNA binding motifs but different RNA binding specificities.
Nucleic acids research - 1 Mar 2001
Sengupta T K, Gordon J, Spicer E K
Abstract excerpt
The RegA proteins from the bacteriophage T4 and RB69 are translational repressors that control the expression of multiple phage mRNAs. RegA proteins from the two phages share 78% sequence identity; however, in vivo expression studies have suggested that the RB69 RegA protein binds target RNAs with a higher affinity than T4 RegA protein. To study the RNA binding properties of T4 and RB69 RegA proteins more...
Topics
- Bacteriophage T4
- Bacteriophages
- Base Sequence
- Binding Sites
- Binding, Competitive
- Conserved Sequence
- Gene Expression
- Helix-Loop-Helix Motifs
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Oligoribonucleotides
- Protein Binding
- Protein Biosynthesis
- RNA, Viral
- RNA-Binding Proteins
- Viral Proteins