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Article

Small variations in multiple parameters account for wide variations in HIV–1 set–points: a novel modelling approach

7 Feb 2001

Abstract excerpt

Steady-state levels of HIV-1 viraemia in the plasma vary more than a 1,000-fold between HIV-positive patients and are thought to be influenced by several different host and viral factors such as host target cell availability, host anti-HIV immune response and the virulence of the virus. Previous mathematical models have taken the form of classical ecological food-chain models and are unable to account for this...

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PMID: 11217892
DOI: 10.1098/rspb.2000.1358

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