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Article

Modeling uncertainty in single-copy assays for HIV.

Journal of clinical microbiology - 1 Oct 2012

Luo Rutao, Piovoso Michael J, Zurakowski Ryan

Abstract excerpt

We present a simple computational model of measurement accuracy for single-copy sensitivity assays (SCA) of HIV RNA that was developed from first principles. The model shows that the SCA is significantly right-skewed. Measured virus concentrations of 1 and 10 virions/ml had overlapping 95% confidence intervals and were statistically indistinguishable.

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Identifiers

PMID: 22837324
DOI: 10.1128/JCM.01254-12
PMCID: PMC3457444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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