Article
A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism.
Science (New York, N.Y.) - 12 Jan 2001
Brune W, Ménard C, Heesemann J, Koszinowski U H
Abstract excerpt
Human cytomegalovirus infects vascular tissues and has been associated with atherogenesis and coronary restenosis. Although established laboratory strains of human cytomegalovirus have lost the ability to grow on vascular endothelial cells, laboratory strains of murine cytomegalovirus retain this ability. With the use of a forward-genetic procedure involving random transposon mutagenesis and rapid phenotypic...
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