Article
Traffic pattern of cystic fibrosis transmembrane regulator through the early exocytic pathway.
Traffic (Copenhagen, Denmark) - 1 Nov 2000
Bannykh S I, Bannykh G I, Fish K N, Moyer B D, Riordan J R, Balch W E
Abstract excerpt
The pathway of transport of the cystic fibrosis transmembrane regulator (CFTR) through the early exocytic pathway has not been examined. In contrast to most membrane proteins that are concentrated during export from the ER and therefore readily detectable at elevated levels in pre-Golgi intermediates and Golgi compartments, wild-type CFTR could not be detected in these compartments using deconvolution...
Topics
- Animals
- Biological Transport, Active
- CHO Cells
- Cell Line
- Cricetinae
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Endoplasmic Reticulum
- Exocytosis
- Golgi Apparatus
- Humans
- Microscopy, Fluorescence
- Microscopy, Immunoelectron
- Models, Biological