Article
Morphine or oxycodone in cancer pain?
Acta oncologica (Stockholm, Sweden) - 1 Jan 2000
Heiskanen T E, Ruismäki P M, Seppälä T A, Kalso E A
Abstract excerpt
Oxycodone is an opioid analgesic that closely resembles morphine. Oxymorphone, the active metabolite of oxycodone, is formed in a reaction catalyzed by CYP2D6, which is under polymorphic genetic control. The role of oxymorphone in the analgesic effect of oxycodone is not yet clear. In this study, controlled-release (CR) oxycodone and morphine were examined in cancer pain. CR oxycodone and morphine were...
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