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Article

Pathogenesis of nerve damage in leprosy: genetic polymorphism regulates the production of TNF alpha.

Leprosy review - 1 Dec 2000

Sarno E N, Santos A R, Jardim M R, Suffys P N, Almeida A S, Nery J A, Vieira L M, Sampaio E P

Abstract excerpt

Studies carried out over the last decade have strongly suggested that TNF alpha both overtly participates in the cell-mediated immune response against Mycobacterium leprae, and is overproduced during reaction. In addition, reactions are intimately related to the onset of nerve damage. Finally, TNF alpha has been implicated in the pathogenesis of many human and experimental autoimmune peripheral neuropathies that,...

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Source

Identifiers

PMID: 11201873
DOI: 10.5935/0305-7518.20000087

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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