Article
Association analysis with microsatellite and SNP markers does not support the involvement of BCL-2 in systemic lupus erythematosus in Mexican and Swedish patients and their families.
Genes and immunity - 1 Aug 2000
Johansson C, Castillejo-López C, Johanneson B, Svenungsson E, Gunnarsson I, Frostegård J, Sturfelt G, Truedsson L, Löfström B, Alcocer-Varela J, Lundberg I, Gyllensten U B, Alarcón-Segovia D, Alarcón-Riquelme M E
Abstract excerpt
We have described suggestive linkage between microsatellite markers within the cytogenetic region 18q21-23 and SLE, a region where linkage with other autoimmune diseases has also been detected. The Bcl-2 gene located within this region, is a candidate gene because of its role in apoptosis, a physiological mechanism that could be deregulated in autoimmune disease. Furthermore, several studies have found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.