Article
Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents.
Acta diabetologica - 1 Jan 2000
Oeffner F, Bornholdt D, Ziegler A, Hinney A, Görg T, Gerber G, Goldschmidt H P, Siegfried W, Wright A, Hebebrand J, Grzeschik K H
Abstract excerpt
Neuromedin B has been shown to exert an inhibiting effect on food consumption in rats. The corresponding gene NMB maps to chromosome 15q22.3-q23, a region expected to contain a gene for the Bardet-Biedl syndrome type 4 (BBS4). Based on its map position and the putative function of the encoded peptide, NMB can be considered as a candidate gene both for BBS4 and the development of human obesity. To examine its...
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