Article
Pathological tau phenotypes. The weight of mutations, polymorphisms, and differential neuronal vulnerabilities.
Annals of the New York Academy of Sciences - 1 Jan 2000
Mailliot C, Bussière T, Hamdane M, Sergeant N, Caillet M L, Delacourte A, Buée L
Abstract excerpt
In tauopathies, comparative biochemistry of tau aggregates shows that they differ in both phosphorylation and content of tau isoforms. Six tau isoforms are found in human brain that contain either three (3R) or four microtubule-binding domains (4R). In Alzheimer's disease, all six of the tau isoforms are phosphorylated and aggregate into paired helical filaments. They are detected by immunoblotting as a major tau...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.