Article
Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.
European journal of neurology - 1 Mar 2009
Ludolph A C, Kassubek J, Landwehrmeyer B G, Mandelkow E, Mandelkow E-M, Burn D J, Caparros-Lefebvre D, Frey K A, de Yebenes J G, Gasser T, Heutink P, Höglinger G, Jamrozik Z, Jellinger K A, Kazantsev A, Kretzschmar H, Lang A E, Litvan I, Lucas J J, McGeer P L, Melquist S, Oertel W, Otto M, Paviour D, Reum T, Saint-Raymond A, Steele J C, Tolnay M, Tumani H, van Swieten J C, Vanier M T, Vonsattel J-P, Wagner S, Wszolek Z K
Abstract excerpt
Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease-modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy,...
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