Article
Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31.
Leukemia - 1 Dec 2000
Xie H, Hu Z, Chyna B, Horrigan S K, Westbrook C A
Abstract excerpt
Human mortalin (HSPA9) was originally identified by its close homology to murine mortalins, which play important roles in cellular senescence. The two murine genes, mot-1 and mot-2, differ in only two amino acid residues, but have opposite functions in cellular immortalization. HSPA9 was recently localized to chromosome 5, band q31, a region that is frequently deleted in myeloid leukemias and myelodysplasia...
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