Article
Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters.
Infection and immunity - 1 Mar 2001
Jiang S M, Wang L, Reeves P R
Abstract excerpt
Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae. CPS gene clusters of S. pneumoniae types 4, 6B, 8, and 18C were sequenced and compared with those of CPS types 1, 2, 14, 19F, 19A, 23F, and 33F. All have the same four genes at the 5' end, encoding proteins thought to be involved in regulation and export. Sequences of these genes can be divided into two classes, and evidence of...
Topics
- Bacterial Capsules
- Base Sequence
- Carbohydrate Sequence
- Conserved Sequence
- Cytidine Diphosphate Diglycerides
- Gene Transfer, Horizontal
- Genes, Bacterial
- Genetic Variation
- Glycosyltransferases
- Intramolecular Transferases
- Molecular Sequence Data
- Multigene Family
- Nucleoside Diphosphate Sugars