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Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A.

Infection and immunity - 15 Oct 2021

Arends D W, Miellet W R, Langereis J D, Ederveen T H A, van der Gaast-de Jongh C E, van Scherpenzeel M, Knol M J, van Sorge N M, Lefeber D J, Trzciński K, Sanders E A M, Dorfmueller H C, Bootsma H J, de Jonge M I

Abstract excerpt

Streptococcus pneumoniae serotype 19A prevalence has increased after the implementation of the PCV7 and PCV10 vaccines. In this study, we have provided, with high accuracy, the genetic diversity of the 19A serotype in a cohort of Dutch invasive pneumococcal disease patients and asymptomatic carriers obtained in the period from 2004 to 2016. The whole genomes of the 338 pneumococcal isolates in this cohort were...

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Identifiers

PMID: 34251291
DOI: 10.1128/IAI.00246-21
PMCID: PMC8519296

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Source receipt: pubmed, retrieved 7 Sept 2026.

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