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Article

The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.

Nature structural biology - 1 Feb 2001

Wu C K, Dailey H A, Rose J P, Burden A, Sellers V M, Wang B C

Abstract excerpt

Human ferrochelatase (E.C. 4.99.1.1) is a homodimeric (86 kDa) mitochondrial membrane-associated enzyme that catalyzes the insertion of ferrous iron into protoporphyrin to form heme. We have determined the 2.0 A structure from the single wavelength iron anomalous scattering signal. The enzyme contains two NO-sensitive and uniquely coordinated [2Fe-2S] clusters. Its membrane association is mediated in part by a...

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PMID: 11175906
DOI: 10.1038/84152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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