Article
Enhanced tumorigenicity caused by truncation of the extracellular domain of GP125/CD98 heavy chain.
Oncogene - 14 Dec 2000
Hara K, Kudoh H, Enomoto T, Hashimoto Y, Masuko T
Abstract excerpt
GP125/CD98 is a heterodimeric 125-kDa glycoprotein, which consists of an 85-kDa heavy chain (hc) and a 40-kDa light chain (lc), and is strongly expressed on the cell surface of various tumor cells, irrespective of their tissue of origin. We have recently demonstrated that overexpression of the CD98hc cDNA causes malignant transformation of NIH3T3 cells. To investigate the function of the extracellular domain of...
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