Article
On estimating the proportion of variance in a phenotypic trait attributable to a measured locus.
Human heredity - 1 Jan 2001
Wijsman E M, Nur N
Abstract excerpt
The measured genotype approach can be used to estimate the variance contributions of specific candidate loci to quantitative traits of interest. We show here that both the naive estimate of measured-locus heritability, obtained by invoking infinite-sample theory, and an estimate obtained from a bias-corrected variance estimate based on finite-sample theory, produce biased estimates of heritability. We identify...
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