Article
Activation of the virus-induced IKK/NF-kappaB signalling axis is critical for the replication of human cytomegalovirus in quiescent cells.
Cellular microbiology - 1 Aug 2007
Caposio Patrizia, Luganini Anna, Hahn Gabriele, Landolfo Santo, Gribaudo Giorgio
Abstract excerpt
Activation of the IKK/NF-kappaB signalling pathway is a hallmark of human cytomegalovirus (HCMV) infection. However, its role in regulating major immediate-early promoter (MIEP)-dependent transcription and HCMV replication remains controversial. This study uses a combination of genetic approaches to investigate the effects of cell culture conditions on the importance of virus-induced NF-kappaB activation during...
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