Article
TP53-dependent chromosome instability is associated with transient reductions in telomere length in immortal telomerase-positive cell lines.
Genes, chromosomes & cancer - 1 Mar 2001
Schwartz J L, Jordan R, Liber H, Murnane J P, Evans H H
Abstract excerpt
Telomere shortening in telomerase-negative somatic cells leads to the activation of the TP53 protein and the elimination of potentially unstable cells. We examined the effect of TP53 gene expression on both telomere metabolism and chromosome stability in immortal, telomerase-positive cell lines. Telomere length, telomerase activity, and chromosome instability were measured in multiple clones isolated from three...
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