Article
Characterization of high-risk HIV-1 seronegative hemophiliacs.
Clinical immunology (Orlando, Fla.) - 1 Feb 2001
Salkowitz J R, Purvis S F, Meyerson H, Zimmerman P, O'Brien T R, Aledort L, Eyster M E, Hilgartner M, Kessler C, Konkle B A, White G C, Goedert J J, Lederman M M
Abstract excerpt
Mechanisms that protect most high-risk HIV-1 seronegative (HRSN) persons are not well understood. Among hemophiliacs from the Multicenter Hemophilia Cohort Study who remained HIV-1 seronegative despite a high (94%) risk for acquisition of HIV-1 infection, only 7/43 were homozygous for the protective CCR5 Delta32 polymorphism. Among the remainder, neither CCR5 density nor beta-chemokine production, nor in vitro...
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