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Article

Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 2001

Volkow N D, Wang G, Fowler J S, Logan J, Gerasimov M, Maynard L, Ding Y, Gatley S J, Gifford A, Franceschi D

Abstract excerpt

Methylphenidate (Ritalin) is the most commonly prescribed psychoactive drug in children for the treatment of attention deficit hyperactivity disorder (ADHD), yet the mechanisms responsible for its therapeutic effects are poorly understood. Whereas methylphenidate blocks the dopamine transporter (main mechanism for removal of extracellular dopamine), it is unclear whether at doses used therapeutically it...

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Identifiers

PMID: 11160455
PMCID: PMC6763805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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