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Article

Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis.

Journal of bacteriology - 1 Feb 2001

Chalker A F, Minehart H W, Hughes N J, Koretke K K, Lonetto M A, Brinkman K K, Warren P V, Lupas A, Stanhope M J, Brown J R, Hoffman P S

Abstract excerpt

A comparative genomic approach was used to identify Helicobacter pylori 26695 open reading frames (ORFs) which are conserved in H. pylori J99 but highly diverged in other eubacteria. A survey of selected pathways of central intermediary metabolism was also carried out, and genes with a potentially selective role in H. pylori were identified. Forty-five ORFs identified in these two analyses were screened using a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome, Bacterial

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Identifiers

PMID: 11157938
DOI: 10.1128/JB.183.4.1259-1268.2001
PMCID: PMC94999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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