Article
Differential effect of rpoB mutations on antibacterial activities of rifampicin and KRM-1648 against Staphylococcus aureus.
The Journal of antimicrobial chemotherapy - 1 Feb 2001
Wichelhaus T, Schäfer V, Brade V, Böddinghaus B
Abstract excerpt
The in vitro antibacterial activities of the rifamycin derivatives rifampicin and KRM-1648 against 150 Staphylococcus aureus isolates were determined. The MICs of rifampicin and KRM-1648 for 90% of rifampicin-susceptible S. aureus isolates (n = 100) were 0.016 and 0.001 mg/L, respectively. In rifampicin-resistant S. aureus isolates (n = 50), different levels of resistance to rifamycins were associated with...
Topics
- Antibiotics, Antitubercular
- DNA-Directed RNA Polymerases
- Drug Resistance, Microbial
- Genes, Bacterial
- Genotype
- Microbial Sensitivity Tests
- Mutation
- Plant Proteins
- Rifampin
- Rifamycins
- Staphylococcus aureus