Matrix metalloproteinases in cancer: prognostic markers and targets for therapy (review).

Abstract excerpt

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases which catalyse degradation of diverse substrates in the extracellular matrix. The family can be loosely divided into 4 subgroups, i.e., interstitial collagenases, gelatinases, stromelysins and membrane-type MMPs. Data from model systems suggest that MMPs are involved in both stimulating tumor cell growth and promoting invasion and metastasis....

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