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Article

Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.

15 Oct 1996

Abstract excerpt

Vaccinia virus, no longer required for immunization against smallpox, now serves as a unique vector for expressing genes within the cytoplasm of mammalian cells. As a research tool, recombinant vaccinia viruses are used to synthesize and analyze the structure-function relationships of proteins, determine the targets of humoral and cell-mediated immunity, and investigate the types of immune response needed for...

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Identifiers

PMID: 8876137
DOI: 10.1073/pnas.93.21.11341

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