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Article

Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2001

Mechtcheriakova D, Schabbauer G, Lucerna M, Clauss M, De Martin R, Binder B R, Hofer E

Abstract excerpt

Tissue factor (TF) has been shown to be up-regulated in endothelial cells by the inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) as well as by the main angiogenic factor VEGF. Since both stimuli induce the transcription factor EGR-1, which is critically involved in TF gene regulation, we used EGR-1-dependent TF induction as a model to identify potential cross-talks between the various signal...

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Source

Identifiers

PMID: 11149911
DOI: 10.1096/fj.00-0247com

Genes

TNF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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