Article
Genetic and developmental analysis of X-inactivation in interspecific hybrid mice suggests a role for the Y chromosome in placental dysplasia.
Genetics - 1 Jan 2001
Hemberger M, Kurz H, Orth A, Otto S, Lüttges A, Elliott R, Nagy A, Tan S S, Tam P, Zechner U, Fundele R H
Abstract excerpt
It has been shown previously that abnormal placental growth, i.e., hyper- and hypoplasia, occurs in crosses and backcrosses between different mouse (Mus) species. A locus that contributes to this abnormal development has been mapped to the X chromosome. Unexpectedly, an influence of fetal sex on placental development has been observed, in that placentas attached to male fetuses tended to exhibit a more pronounced...
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