Article
Drosophila Lyra mutations are gain-of-function mutations of senseless.
Genetics - 1 Jan 2001
Nolo R, Abbott L A, Bellen H J
Abstract excerpt
The Lyra mutation was first described by Jerry Coyne in 1935. Lyra causes recessive pupal lethality and adult heterozygous Lyra mutants exhibit a dominant loss of the anterior and posterior wing margins. Unlike many mutations that cause loss of wing tissue (e.g., scalloped, Beadex, cut, and apterous-Xasta), Lyra wing discs do not exhibit increased necrotic or apoptotic cell death, nor do they show altered BrdU...
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