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Article

Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastases

1 Jan 2001

Abstract excerpt

Amplification and overexpression of the c-myc gene have been associated with neoplastic transformation in a plethora of malignant tumours. We applied interphase fluorescence in situ hybridization (FISH) with a locus-specific probe for the c-myc gene (8q24) in combination with a corresponding chromosome 8 alpha-satellite probe to evaluate genetic alterations in 8 primary melanomas and 33 advanced melanomas and...

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Identifiers

PMID: 11139316
DOI: 10.1054/bjoc.2000.1535

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