Article
New approaches for genotyping of Helicobacter pylori based on amplification of polymorphisms in intergenic DNA regions and at the insertion site of the cag pathogenicity island.
Medical microbiology and immunology - 1 Nov 2000
Bereswill S, Schönenberger R, Thies C, Stähler F, Strobel S, Pfefferle P, Wille L, Kist M
Abstract excerpt
The population of the gastric pathogen Helicobacter pylori shows a high degree of genetic diversity. It is well established that heterogeneity at the isolate level is caused by nucleotide transitions within genes, differences in the gene order, and by genetic instability of single genes as well as of a large virulence-associated genomic DNA region, the cag pathogenicity island (PAI). Analysis of intergenic...
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