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Article

Pathogenicity island cag, vacA and IS605 genotypes in Mexican strains of Helicobacter pylori associated with peptic ulcers.

Annals of clinical microbiology and antimicrobials - 13 May 2011

Antonio-Rincón Fernando, López-Vidal Yolanda, Castillo-Rojas Gonzalo, Lazcano-Ponce Eduardo C, Ponce-de-León Sergio, Tabche-Barrera María L, Aguilar-Gutiérrez Germán R

Abstract excerpt

BACKGROUND: Helicobacter pylori is associated with chronic gastritis, peptic ulcers, and gastric cancer. Two major virulence factors of H. pylori have been described: the pathogenicity island cag (cag PAI) and the vacuolating cytotoxin gene (vacA). Virtually all strains have a copy of vacA, but its genotype varies. The cag PAI is a region of 32 genes in which the insertion of IS605 elements in its middle region...

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Identifiers

PMID: 21569518
DOI: 10.1186/1476-0711-10-18
PMCID: PMC3118320

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