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Dengue virus binding and replication by platelets

6 May 2015

Abstract excerpt

Dengue virus (DENV) infection causes ∼200 million cases of severe flulike illness annually, escalating to life-threatening hemorrhagic fever or shock syndrome in ∼500,000. Although thrombocytopenia is typical of both mild and severe diseases, the mechanism triggering platelet reduction is incompletely understood. As a probable initiating event, direct purified DENV-platelet binding was followed in the current...

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PMID: 25943787
DOI: 10.1182/blood-2014-09-598029

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