Article
Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2001
Chun T W, Justement J S, Moir S, Hallahan C W, Ehler L A, Liu S, McLaughlin M, Dybul M, Mican J M, Fauci A S
Abstract excerpt
CD8+ T cell-mediated antiviral activity against HIV has been described consistently in infected individuals; however, the role of this activity in controlling replication of HIV in the latently infected, resting CD4+ T cell reservoir is unclear. By using an ex vivo system, we show that replication of HIV in this viral reservoir is effectively suppressed in coculture by autologous CD8+ T cells in long-term...
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