Modeling HIV-1 Latency Using Primary CD4+T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy

Abstract excerpt

Primary cell models of HIV latency have been very useful to identify mechanisms contributing to HIV latency and to evaluate potential HIV cure strategies. However, the current models utilizein vitroinfection with exogenous virus that does not fully recapitulate virus reactivation profiles of endogenous HIV inin vivo-infected CD4+T cells. In contrast, obtaining sufficient amounts of CD4+T cells from HIV-infected...

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