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A Spectrum of Changes Occurs in Peptidoglycan Composition of Glycopeptide-Intermediate Clinical <i>Staphylococcus aureus</i> Isolates

1 Jan 2001

Abstract excerpt

The mechanism of glycopeptide resistance in Staphylococcus aureus is not known with certainty. Because the target of vancomycin is the D-Ala-D-Ala terminus of the stem peptide of the peptidoglycan precursor, by subjecting muropeptides to reversed-phase high-performance liquid chromatography, we investigated peptidoglycan obtained from glycopeptide-intermediate S. aureus (GISA) isolates for changes in composition...

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Identifiers

PMID: 11120978
DOI: 10.1128/aac.45.1.280-287.2001

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