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Article

Somatic alterations of the androgen receptor CAG repeat in human colon cancer delineate a novel mutation pathway independent of microsatellite instability.

Cancer genetics and cytogenetics - 1 Nov 2000

Ferro P, Catalano M G, Raineri M, Reato G, dell'Eva R, Risio M, Foà R, Fortunati N, Pfeffer U

Abstract excerpt

The human androgen receptor gene contains a polymorphic CAG repeat region ranging from 8 to about 35 repeats in the normal human population. The repeat length is inversely related to the transactivation potential of the receptor. We have analyzed the repeat length in 50 sporadic colon cancer samples in comparison to surrounding healthy mucosa and have found somatic reductions of up to 10 repeats in 5 cases (10%),...

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PMID: 11120331
DOI: 10.1016/s0165-4608(00)00296-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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