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Article

Group A streptococcal rofA gene is involved in the control of several virulence genes and eukaryotic cell attachment and internalization.

Infection and immunity - 1 Jan 2001

Beckert S, Kreikemeyer B, Podbielski A

Abstract excerpt

The serotype M6 group A streptococcal RofA regulator was previously shown to exert a direct positive control of protein F1 expression and, concomitantly, fibronectin binding. Using a serotype M6 rofA mutant, we demonstrate here that this regulator has a potentially indirect negative influence on the expression of the mga, emm6, pel-sagA, and speA virulence genes. Additionally, the rofA mutant exhibited reduced...

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Identifiers

PMID: 11119547
DOI: 10.1128/IAI.69.1.534-537.2001
PMCID: PMC97913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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