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Article

MgrA Activates Staphylococcal Capsule via SigA-Dependent Promoter.

Journal of bacteriology - 18 Dec 2020

Lei Mei G, Lee Chia Y

Abstract excerpt

Staphylococcus aureus capsule polysaccharide is an important antiphagocytic virulence factor. The cap genes are regulated at the promoter element (Pcap) upstream of the cap operon. Pcap, which consists of a dominant SigB-dependent promoter and a weaker upstream SigA-dependent promoter, is activated by global regulator MgrA. How MgrA activates capsule is unclear. Here, we showed that MgrA directly bound to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33077637
DOI: 10.1128/JB.00495-20
PMCID: PMC7950413

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