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Article

Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Dec 2000

Chappuis P O, Kapusta L, Bégin L R, Wong N, Brunet J S, Narod S A, Slingerland J, Foulkes W D

Abstract excerpt

PURPOSE: Decreased levels of the cyclin-dependent kinase inhibitor p27(Kip1) in breast cancer are associated with a poor outcome. The prognostic significance of BRCA1/2 mutations is less clear, and the relationship between BRCA1/2 mutation status, p27(Kip1) protein levels, and outcome has not been studied. PATIENTS AND METHODS: Pathology blocks from 202 consecutive Ashkenazi Jewish women with primary invasive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11118465
DOI: 10.1200/JCO.2000.18.24.4045

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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