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Article

Impact of germline <i>BRCA1</i> mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma

17 Jan 2003

Abstract excerpt

BACKGROUND: Overexpression of p53 has been associated with poor survival following breast carcinoma. BRCA1 interacts biochemically with p53 and may also contribute to poor outcome when constitutionally mutated. The joint effect of both abnormalities has not been studied. The primary objective of this study was to assess the impact of germline BRCA1 mutations and p53 overexpression on survival after 10 years of...

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PMID: 12548593
DOI: 10.1002/cncr.11080

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