Article
Apolipoprotein E genotype and oxidative stress response to traumatic brain injury.
Neuroscience - 14 Jul 2010
Ferguson S, Mouzon B, Kayihan G, Wood M, Poon F, Doore S, Mathura V, Humphrey J, O'Steen B, Hayes R, Roses A, Mullan M, Crawford F
Abstract excerpt
Traumatic Brain Injury (TBI) is known to result in oxidative stress, and as variation at the Apolipoprotein E (APOE) gene has been shown to influence outcome following TBI, but through as yet unclear mechanisms, we used transgenic APOE mouse models to examine the relationship between APOE genotype and oxidative stress following TBI. We administered a controlled cortical impact (CCI) injury or sham injury to...
Topics
- Animals
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Brain Injuries
- Genotype
- Humans
- Mice
- Mice, Transgenic
- Oligonucleotide Array Sequence Analysis
- Oxidation-Reduction