Article
Compensating for our load of mutations: freezing the meltdown of small populations.
Evolution; international journal of organic evolution - 1 Oct 2000
Poon A, Otto S P
Abstract excerpt
We have investigated the reduction of fitness caused by the fixation of new deleterious mutations in small populations within the framework of Fisher's geometrical model of adaptation. In Fisher's model, a population evolves in an n-dimensional character space with an adaptive optimum at the origin. The model allows us to investigate compensatory mutations, which restore fitness losses incurred by other...
Topics
- Animals
- Biological Evolution
- Computer Simulation
- Gene Dosage
- Gene Frequency
- Genetics, Population
- Humans
- Markov Chains
- Models, Genetic
- Models, Statistical
- Mutation
- Probability