Complexity, pleiotropy, and the fitness effect of mutations.

doi:10.1111/j.1558-5646.2011.01237.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Complexity, pleiotropy, and the fitness effect of mutations.

Evolution; international journal of organic evolution - 1 Jun 2011

Lourenço João, Galtier Nicolas, Glémin Sylvain

Abstract excerpt

One of the assumptions underlying many theoretical predictions in evolutionary biology concerns the distribution of the fitness effect of mutations. Approximations to this distribution have been derived using various theoretical approaches, of which Fisher's geometrical model is among the most popular ones. Two key concepts in this model are complexity and pleiotropy. Recent studies have proposed different...

Topics

Computer Simulation
Evolution, Molecular
Genetic Fitness
Genetic Pleiotropy
Models, Genetic
Mutation
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 21644948
DOI: 10.1111/j.1558-5646.2011.01237.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics