Article
Haemophilus influenzae Protein F Mediates Binding to Laminin and Human Pulmonary Epithelial Cells
10 Dec 2012
Abstract excerpt
The mucosal pathogen nontypeable Haemophilus influenzae (NTHi) adheres to the respiratory epithelium or, in the case of epithelial damage, to the underlying basement membrane and extracellular matrix that, among other proteins, consists of laminin. We have recently identified protein F, an ABC transporter involved in NTHi immune evasion. Homology modeling of the protein F tertiary structure revealed a strong...
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