Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.

Human molecular genetics - 22 Nov 2000

Hilditch-Maguire P, Trettel F, Passani L A, Auerbach A, Persichetti F, MacDonald M E

Abstract excerpt

Huntington's disease (HD), with its selective neuronal cell loss, is caused by an elongated glutamine tract in the huntingtin protein. To discover the pathways that are candidates for the protein's normal and/or abnormal function, we surveyed 19 classes of organelle in Hdh(ex4/5)/Hdh(ex4/5) knock-out compared with wild-type embryonic stem cells to identify any that might be affected by huntingtin deficiency....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomes
Share to Exportin 1 Protein
Share to Fatty Acids, Unsaturated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Intracellular Membranes

Share to Karyopherins

Share to Organelles

Share to Receptors, Transferrin

Source

Identifiers

PMID: 11092755
DOI: 10.1093/hmg/9.19.2789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.PMID 11092755Read ↗

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.Semantic proximity Read ↗

Proteomics of Huntington's disease-affected human embryonic stem cells reveals an evolving pathology involving mitochondrial dysfunction and metabolic disturbances.Semantic proximity Read ↗

Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.Semantic proximity Read ↗

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.Semantic proximity Read ↗

Oxidative damage in Huntington's disease pathogenesis.Semantic proximity Read ↗

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells.Semantic proximity Read ↗

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity.Semantic proximity Read ↗

Biphasic Temporal Remodeling Of The Proteome In A Polyglutamine-Expanded Huntingtin In Vitro Aggregation Cell Model: From Early Rna-Regulatory Compensation To Selective Mitochondrial Energy FailureSemantic proximity Read ↗

Atp7a deficiency induces axonal and myelin developmental defects in zebrafish via ferroptosisSemantic proximity Read ↗

WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism.Semantic proximity Read ↗

Hepatic <i>huntingtin</i> loss drives an acute phase response and liver injury in multiple mouse modelsSemantic proximity Read ↗

Iron Accumulation and Changes in Cellular Organelles in WDR45 Mutant Fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.