Article
Nonsense mutation in exon V of the factor XI gene does not abolish platelet factor XI expression.
British journal of haematology - 1 Oct 2000
Shirk R A, Konkle B A, Walsh P N
Abstract excerpt
Factor XI (FXI) is a plasma glycoprotein produced by the liver that plays an essential role in blood coagulation. Individuals deficient in this protein are prone to bleeding following trauma or surgery. Well-washed platelets possess FXI-like activity and FXI antigen that differs in molecular weight from plasma FXI and is associated with FXI mRNA from platelets in which exon V is absent. Some individuals deficient...
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